The most severe type of HIV infection is represented by the disease known as AIDS. AIDS is characterized by intractable immune deficit, rare malignant neoplasms, and opportunistic infections. The main objective of this study was to do a systematic review to examined the effects of yoga intervention on Acquired Immunodeficiency Syndrome (AIDS). Data was collected from PubMed and Web of Science. Randomized controlled trials published in English from the inception of the database until 31st October, 2025, were included. It may be concluded that one promising stress-reduction strategy is yoga. However, the restricted number of research limits the literature. To further assess the advantages of yoga, randomized controlled trials using objective metrics of HIV-related outcomes are required.