Result: The baseline and post-assessment will be performed after 21 days for all the individuals; homeostatic model assessment of insulin resistance (HOMA-IR). Descriptive statistics such as means and standard deviations will be calculated for each variable measured by the HOMA-IR. Additionally, inferential statistics such as t-tests will be performed to compare the HOMA-IR value between intervention and control groups. The level of significance will be set at p≤0.05. Any outliers or missing data points will be carefully addressed and handled accordingly.

Discussion: The SNP is a simple effective technique, 21 days of SNP might improve HOMA-IR, which may be recommended as an adjuvant therapy for T2DM patients along with conventional care. The study is prospectively registered in the Clinical Trial Registry of India (CTRI/2024/05/065088) and International Institute of Yoga and Naturopathy Medical Sciences Ethical Committee (IEC) approval was obtained; vide letter number 446/ME-II/2023.