Introduction: Breast cancer shows the high prevalence and mortality among the women. The Integrating supplementary therapies like yoga has shown promise in enhancing the well-being and overall health outcomes of breast cancer patients. This study aims to explore the effects of yoga therapy on physiological indicators, including Red Blood Cell (RBC) count, White Blood Cell (WBC) count, and Bilirubin levels, in breast cancer patients during a 48-week intervention.

Materials and Methods: A cohort of 48 Stage II/III breast cancer patients undergoing radiotherapy and/or chemotherapy participated in the study. Certified yoga instructors conducted sessions comprising asanas. RBC count, WBC count, and Bilirubin levels were measured at baseline, 16 weeks, 32 weeks, and 48 weeks. Statistical analysis employed one-way ANOVA and Kruskal-Wallis tests.

Results: The study demonstrated a significant increase in RBC count in patients aged < 45 years from baseline to 48 weeks (p<0.0001), suggesting potential positive effects of yoga therapy, particularly in younger patients. Bilirubin levels exhibited significant changes over time, with increases observed at 16 weeks, 32 weeks, and 48 weeks compared to baseline (p<0.001). However, no significant changes in WBC count were observed during the intervention period.

Conclusion: Yoga therapy showed promising effects on Bilirubin levels, platelets and RBC count in breast cancer patients, particularly in the younger age group. These findings support the potential inclusion of yoga as a complementary approach in breast cancer management. The evidence supporting the potential role of yoga therapy in breast cancer care, offering prospects for improved health outcomes and enhanced quality of life for patients.