The objective of this study was to determine the comparative effect of yogic practices and brisk walking on low density lipoprotein of middle aged men. The subjects for this study were sedentary male from Gwalior. Total of ninety male subjects were selected and used as two experimental groups (30 subjects each) and control group (30 subjects). Yogic practices and brisk walking were considered the independent variables and low-density lipoprotein was considered as the dependent variable. 2 ml of blood in plain vial was taken as the criterion measures. Training was given for twelve weeks with each session of 45 minutes. The Pre Test- Post Test randomized group design was used for this study. Tests were administered before the training program and after the completion of the treatment again test were administered. ANCOVA was used to locate significant effects of yogic practices and brisk walking on low density lipoprotein at 0.05 levels of significance. In relation to low density lipoprotein, brisk walking group was found to be better in decreasing the low density lipoprotein level in blood than yogic practices group.