Background: Osteoarthritis (OA) is the most prevalent chronic disease and is a leading cause of pain and disability in most countries worldwide.

Objective: To see the effect of the yoga program on patients with osteoarthritis of the knee.

Design: single group longitudinal pre-post study.

Setting: The study was conducted on thirty patients with KOA in residential health care Centre in Hissar, Haryana, India, between the periods of September to December 2022.

Participants: 30 patients in which 28 women and 2 males with symptomatic knee osteoarthritis.

Intervention: yoga practices intended to act physically, emotionally, Intellectually, and spiritually level and includes yoga postures, breathing exercises, internal cleansing techniques, meditation, pranayama, and relaxation techniques for one weak.

Measurements: WOMAC.

Results: While calculating the data with the help of SPSS 26 Version calculating significance value is 0.00 which is less than the level of significance.

Conclusion: Results of this study showed a beneficial effect in reducing the cardinal symptoms of OAK. Therefore, yoga therapy can be used as an alternative and complementary therapy in OAK.