There was a significant increase in hemoglobin and significant decrease in ESR levels a result of Yoga practices as the result shows statistically significant “t” value. Changes in these parameters may be due to improved immunity and better endurance capacity in the practitioners. Yoga improved the overall health of the subjects practicing Paschimottanasana and Shavian. A comprehensive yoga therapy program has the potential to enhance the beneficial effects of standard medical management of diabetes mellitus and can be used as an effective complementary or integrative therapy program.